CHROMOSOME ANALYSIS HIGH RESOLUTION BLOOD
General Information
HLAB/HOL Code: CYG
UPHSM LIS Test #:
Schedule: Monday-Friday
Testing Time: 3 - 7 days
Testing Lab: UP Health System-Marquette
UPHSM LIS Test #:
Schedule: Monday-Friday
Testing Time: 3 - 7 days
Testing Lab: UP Health System-Marquette
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 5.0 mL Whole Blood
Temperature: Ambient
Tube Type: 1 Green Top (Sodium Heparin)
Collection Info:
Draw a minimum of 5.0 mL of blood into green-top (sodium heparin) tube(s), invert several times to mix (clotted blood will not work.) Other anticoagulants may be harmful to the viability of the cells. Label vial with patient's name and a unique identifying number (MGHS encounter #or MR #). Maximum time from collection should be 48 hours.
SPECIMENS CANNOT BE FROZEN
Temperature: Ambient
Tube Type: 1 Green Top (Sodium Heparin)
Collection Info:
Draw a minimum of 5.0 mL of blood into green-top (sodium heparin) tube(s), invert several times to mix (clotted blood will not work.) Other anticoagulants may be harmful to the viability of the cells. Label vial with patient's name and a unique identifying number (MGHS encounter #or MR #). Maximum time from collection should be 48 hours.
SPECIMENS CANNOT BE FROZEN
Methods
Includes GTG banding, 20 metaphases counted, 5 analyzed, and 3 karyogrammed, including at least one metaphase of representative length and banding for the case. High-resolution band length should be equal to or greater than 650
bands.
bands.
Clinical Utilities
High-resolution chromosome analysis is useful in detecitng small chromosome abnormalities undectable by routine methods and precisely identifying chromosome abnormalities previously detected by routine methods. It is strongly recommended for all congenital anomalies, mental retardation (MR), growth retardation, developmental delay (DD), dysmorphic features, phenotype suggestive of microdeletion syndromes, positive family history of abnormal pregnancy outcome, and autistic spectrum disorders (ASD).
CPT Codes
88230 (Tissue culture lymphocyte), 88262 (Chromosome analysis 15-20 cells), 88289 (Chromosome analysis, additional high resolution study), 88291 (Interpretation and reporting). The following CPT codes are added as needed at additional charge: 88280 (additional karyotypes), 88285 (additional cells), 88261 (Family screen for previously diagnosed abnormality; 5 cells and 1 karyotype).
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference Range
46,XX or 46,XY. No apparent abnormality.
