FISH ANALYSIS FIP1L1-PDGFRA CHIC2
General Information
HLAB/HOL Code: FISH
UPHSM LIS Test #: 2514
Schedule: Monday-Friday
Testing Time: 2-5 Days
Testing Lab: UP Health System-Marquette
UPHSM LIS Test #: 2514
Schedule: Monday-Friday
Testing Time: 2-5 Days
Testing Lab: UP Health System-Marquette
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 3.0 mL Bone Marrow or 5.0 mL Blood
Temperature: Ambient
Tube Type: Sodium Heparin
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease. Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results). Label vial with the patient's name and a unique identifying number (MGHS encounter # or MR #). Maximum time from collection should be 24 hours.
SPECIMENS CANNOT BE FROZEN
Temperature: Ambient
Tube Type: Sodium Heparin
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease. Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results). Label vial with the patient's name and a unique identifying number (MGHS encounter # or MR #). Maximum time from collection should be 24 hours.
SPECIMENS CANNOT BE FROZEN
Methods
Fluorescence in situ hybridization (FISH) interphase set-up and analysis for FIP1L1-PDGFRA-CHIC2 gene alterations. A minimum of 200 interphase nuclei will be analyzed.
Clinical Utilities
Detection of the FIP1-like 1 (FIP1L1) and platelet derived growth factor receptor alpha gene product associated with chronic hypereosinophilia with systemic mast cell disease. The FIP1L1 and PDGFR alpha fusion is a known target for imatinib mesylate therapy.
CPT Codes
CALL FOR CPTs
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference Range
An interpretive report will be provided.
