GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) QUANTITATIVE

General Information

HLAB/HOL Code: G6PD
UPHSM LIS Test #: 629
Schedule: Monday-Friday
Testing Time: 2 - 4 Days
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 2 full 4mL tubes
Temperature: Refrigerate
Tube Type: Whole Blood
Collection Info:
Minimum Volume: Hemoglobin: two 500-μL lavender-top Microtainer™ tubes filled to at least 50% of tube capacity (Note: If any other size lavender tube is used, the tube must be filled to at least 50% capacity of tube fill volume. Insufficient volume may limit the extent of procedures performed.); and G6PD: one lavender-top (EDTA) tube, green-top (heparin) tube, or yellow-top (ACD) tube (0.1 mL) whole blood.
Container: Two lavender-top (EDTA) tubes or one green-top (heparin) tube and one lavender-top (EDTA) tube or one yellow-top (ACD) tube and one lavender-top (EDTA) tube

Methods

Kinetic − 340 nm

Clinical Utilities

Evaluate glucose 6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency, an X-linked disorder, is the most common enzymatic disorder of red blood cells in humans, affecting more than 400 million people worldwide. The clinical expression of G6PD variants encompasses a spectrum of hemolytic syndromes. Affected patients are most often asymptomatic, but many patients have episodic anemia, while a few have chronic hemolysis. With the most prevalent G6PD variants (G6PD A- and G6PD Mediterranean), hemolysis is induced in children and adults by the sudden destruction of older, more deficient erythrocytes after exposure to drugs having a high redox potential (including the antimalarial drug primaquine and certain sulfa drugs) or to fava beans, selected infections, or metabolic abnormalities. In the neonate with G6PD deficiency, however, decreased bilirubin elimination may play an important role in the development of jaundice. G6PD deficiency should be suspected in any subject with an episode of nonimmune hemolytic anemia, especially if occurring after drug ingestion, infection, or an episode of diabetic ketoacidosis.

CPT Codes

82955

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

See Report.