General Information

UPHSM LIS Test #: 029114
Testing Time: 1-2
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 0.5 mL
Temperature: Frozen
Tube Type: Serum
Collection Info:
Minimum Volume: 0.2 mL
Container: Red-top tube or gel-barrier tube

Specimen Acceptability

Cause for Rejection:
Hemolysis; lipemia; grossly icteric, visible particulate matter; gross bacterial contamination


Chemiluminescent immunoassay (CLIA)

Clinical Utilities

Aid in the diagnosis of EBV infections (infectious mononucleosis). EBV nuclear antigen (EBNA) IgG antibodies do not appear during the acute phase of infection but appear around 2-4 months after initial clinical presentation and typically persist for life. The presence of EBNA IgG antibodies in healthy individuals typically indicates past immunological exposure to EBV; however, false positive results can occur. Additionally, approximately 5-10% of individuals infected with EBV never develop EBNA IgG antibodies. Because of the complex relationship that exists between the EBV virus/host reaction and clinical manifestation, tracking of EBV antibody patterns may assist in diagnosis of EBV infection. Individual levels of specific antibodies are not necessarily indicative of disease state but can be of diagnostic significance when tracked as an antibody response profile. Antibody response profiles for the different EBV antigens demonstrate a characteristic pattern for silent primary or persistent latent EBV infections, as well as for each of the EBV-associated disease.

CPT Codes


* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.