LEVETIRACETAM

General Information

HLAB/HOL Code: LEVET
UPHSM LIS Test #: 9494
Schedule:
Testing Time:
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 1.0 mL (0.2 min) serum
Temperature: Ambient
Tube Type: 1 Red top tube
Collection Info:
Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Transfer separated serum to a plastic transport tube.
Volume: 1.0 mL (0.2 min) plasma
Temperature: Ambient
Tube Type: 1 EDTA or Heparin tube
Collection Info:
Transfer separated plasma to a plastic transport tube.

Methods

LC/MS/MS

Clinical Utilities

Levetiracetam (LTA), a piracetam analogue, is an antiepileptic drug (AED) structurally unrelated to other AEDs. The exact mechanism by which LTA acts has not been determined at this time; however, binding sites for the drug have been identified in synaptic plasma membranes of CNS neurons. Secondary alteration in GABA-related enzymes may result from binding to neurons in specific regions of the CNS.  While approximately one-fourth of LTA is converted by enzymatic hydrolysis to a carboxylic acid metabolite, the drug has no effect on UDP glucuronyltransferase, epoxide hydrolase, or enzymes in the CYP system, resulting in minimal interactions with other AEDs in a polypharmacy regimen. LTA has minimal protein binding (<10%), an elimination half-life of six to eight hours in healthy adults, six hours in children, and 10-11 hours in the elderly. In healthy adults, approximately 95% of LTA and metabolites are excreted in the urine. Renal impairment can, therefore, decrease clearance from 35% to 60%.  

A single 1000 mg dose or 1000 mg twice daily doses produced peak levels of 31 μg/mL and 43 μg/mL, respectively.  Neuropsychiatric adverse events of aggression, anger, and irritability, as well as adverse reactions of leukopenia, neutropenia, pancytopenia, and thrombocytopenia have been reported.

CPT Codes

80177

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

10.0 - 40.0 ug/mL