METANEPHRINES FRACTIONATED QUANTITATIVE 24-HOUR URINE

General Information

HLAB/HOL Code: MET
UPHSM LIS Test #: 4684
Schedule:
Testing Time:
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 10 mL
Temperature: Ambient
Tube Type: 24 hour urine
Collection Info:
Minimum Volume: 2.5 mL aliquot (Note: This volume does not allow for repeat testing.)
Container: Plastic urine container with no preservative or 6N HCl
Collection: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Label container with patient's name, date and time collection started, and date and time collection finished. Measure and record total 24-hour volume. Mix well; send aliquot.

Methods

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Clinical Utilities

Evaluation of catecholamine-secreting tumors of the adrenal medulla (pheochromocytomas) and extra-adrenal sympathetic and parasympathetic paragangliomas.


CPT Codes

83835

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

Pediatric and adults:

Normetanephrine (normotensive):
• 0-2 years: not established
• 3-8 years: 13-252 μg/24 hours
• 9-12 years: 32-346 μg/24 hours
• 13-17 years: 63-402 μg/24 hours
• >17 years: 82-500 μg/24 hours

Normetanephrine (hypertensive):
2 >17 years: 110-1050 μg/24 hours

Metanephrine (normotensive):
• 0-2 years: not established
• 3-8 years: 5-113 μg/24 hours
• 9-12 years: 21-154 μg/24 hours
• 13-17 years: 32-167 μg/24 hours
• >17 years: 45-290 μg/24 hours

Metanephrine (hypertensive):
2 >17 years: 35-460 μg/24 hours