MATERNAL SERUM INTEGRATED SCREEN PART I
General Information
HLAB/HOL Code: MSIP1
UPHSM LIS Test #: 5697
Schedule: Daily
Testing Time: 2-5 Days
Testing Lab: Labcorp
UPHSM LIS Test #: 5697
Schedule: Daily
Testing Time: 2-5 Days
Testing Lab: Labcorp
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 3.0 (1.0)mL Serum
Temperature: Ambient
Tube Type: Gel-Barrier Tube
Collection Info:
Collection: Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (ie, prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Integrated Serum Form. Testing provided from 10.0 to 13.9 weeks of gestation.
Temperature: Ambient
Tube Type: Gel-Barrier Tube
Collection Info:
Collection: Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (ie, prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Integrated Serum Form. Testing provided from 10.0 to 13.9 weeks of gestation.
Specimen Acceptability
Cause for Rejection:
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
Methods
Chemiluminescent immunoassay
Clinical Utilities
Use:
Screening test for open neural tube defects, Down syndrome, and trisomy 18
Limitations:
Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine whether a neural tube defect or chromosome abnormality is present.
Screening test for open neural tube defects, Down syndrome, and trisomy 18
Limitations:
Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine whether a neural tube defect or chromosome abnormality is present.
CPT Codes
84163
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference Range
Result interpretation will be provided only when the second trimester specimen is received and tested.
