INTERLEUKIN 28B (IL28B) POLYMORPHISM (rS12979860)

HLAB/HOL Code: IL28B
UPHSM LIS Test #: 027937
Schedule:
Testing Time: 5-7 Days
Testing Lab: Labcorp

Cause for Rejection:
Frozen specimen; hemolysis; quantity not sufficient; improper container; one buccal swab; wet buccal swab

Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs12979860) upstream of the IL28B gene, which is associated with higher sustained viral response rates to pegylated interferon/ribavirin therapy in HCV genotype 1-infected individuals. The CC genotype, as compared to either the CT or TT genotypes, has been associated with an approximately twofold to threefold greater rate of sustained viral response in hepatitis C virus genotype 1 chronically-infected individuals treated with combination pegylated interferon/ribavirin therapy.  Similar sustained viral response associations across various racial groups including European Americans (95% CI 1.8-2.3), African Americans (95% CI 1.9-4.7), and Hispanics (95% CI 1.4-3.2) have been observed.  The CC genotype has also been associated with a threefold increase in rate of spontaneous clearance of HCV.  Allele frequencies for the rs12979860 C allele vary across racial and ethnic groups. The rs12979860 C variant is most frequently present in individuals from East Asia (allele frequency >0.9) and least common in individuals of African origin (allele frequency 0.2-0.5).2 In a recent US-based study, the favorable CC genotype was observed in 37% of Caucasians, 29% of Hispanics, and 14% of African Americans tested.

An Interpretative Report Sent