CRYOGLOBULIN SERUM AND PLASMA
General Information
HLAB/HOL Code: CRYF
UPHSM LIS Test #: 026850
Schedule:
Testing Time: 2-10 Days
Testing Lab: Mayo
UPHSM LIS Test #: 026850
Schedule:
Testing Time: 2-10 Days
Testing Lab: Mayo
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 1.0 mL
Temperature: Refrigerated
Tube Type: Plasma
Collection Info:
BOTH PLASMA AND SERUM ARE REQUIRED
Collection Instructions:
1. Tube must remain at 37 degrees C.
2. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees
C until after separation of plasma from red cells.
3. Place plasma into an appropriately labeled plastic vial.
Temperature: Refrigerated
Tube Type: Plasma
Collection Info:
BOTH PLASMA AND SERUM ARE REQUIRED
Collection Instructions:
1. Tube must remain at 37 degrees C.
2. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees
C until after separation of plasma from red cells.
3. Place plasma into an appropriately labeled plastic vial.
Volume: 5.0 mL
Temperature: Refrigerated
Tube Type: Serum
Collection Info:
BOTH PLASMA AND SERUM ARE REQUIRED
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Collection Instructions:
1. Tube must remain at 37 degrees C.
2. Allow blood to clot at 37 degrees C.
3. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees
C until after separation of serum from red cells.
4. Place serum into an appropriately labeled plastic vial.
Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require draw of a new specimen.
Temperature: Refrigerated
Tube Type: Serum
Collection Info:
BOTH PLASMA AND SERUM ARE REQUIRED
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Collection Instructions:
1. Tube must remain at 37 degrees C.
2. Allow blood to clot at 37 degrees C.
3. Centrifuge at 37 degrees C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37 degrees
C until after separation of serum from red cells.
4. Place serum into an appropriately labeled plastic vial.
Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require draw of a new specimen.
Specimen Acceptability
REJECT DUE TO:
Gross hemolysis: OK
Gross lipemia: OK
Gross icterus: OK
Gross hemolysis: OK
Gross lipemia: OK
Gross icterus: OK
Methods
CRY_S, CRY_P: Quantitation and Qualitative Typing Precipitation at 1 Degree C
Includes cryofibrinogen.
IMFXC: Immunofixation
Includes cryofibrinogen.
IMFXC: Immunofixation
Clinical Utilities
Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases
Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure
This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.
Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure
This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.
CPT Codes
82585
82595
86334-Immunofixation (if appropriate)
82595
86334-Immunofixation (if appropriate)
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference Range
CRYOGLOBULIN
Negative (positives reported as percent)
If positive after 1 or 7 d, immunotyping of the
cryoprecipitate is performed.
CRYOFIBRINOGEN
Negative (reported as positive or negative)
Quantitation and immunotyping will not be
performed on positive cryofibrinogen.
Negative (positives reported as percent)
If positive after 1 or 7 d, immunotyping of the
cryoprecipitate is performed.
CRYOFIBRINOGEN
Negative (reported as positive or negative)
Quantitation and immunotyping will not be
performed on positive cryofibrinogen.
Component Info
Name: CRYOGLOBULIN
Method: Precipitation at 1 degree C
CPT Code: 82595
Ref Range: CRYOGLOBULINNegative (positives reported as percent)If positive after 1 or 7 days, immunoelectrophoresis of the cryo-precipitate is performed. A narrative report is provided.All samples are reviewed 1 week after initial reading for delayed precipita
Comp Units:
Method: Precipitation at 1 degree C
CPT Code: 82595
Ref Range: CRYOGLOBULINNegative (positives reported as percent)If positive after 1 or 7 days, immunoelectrophoresis of the cryo-precipitate is performed. A narrative report is provided.All samples are reviewed 1 week after initial reading for delayed precipita
Comp Units:
Name: CRYPFIBRINOGEN
Method: Precipitation at 1 degree C
CPT Code: 82585
Ref Range: CRYOFIBRINOGENNegative (reported as positive or negative)Quantitation and immunoelectrophoresis will not be performed onpositive cryofibrinogen.
Comp Units:
Method: Precipitation at 1 degree C
CPT Code: 82585
Ref Range: CRYOFIBRINOGENNegative (reported as positive or negative)Quantitation and immunoelectrophoresis will not be performed onpositive cryofibrinogen.
Comp Units:
