CREATINE KINASE (CK) TOTAL PLUS ISOENZYMES ELECTROPHORESIS SERUM
General Information
HLAB/HOL Code: CKELC
UPHSM LIS Test #: 026336
Schedule:
Testing Time:
Testing Lab: Labcorp
UPHSM LIS Test #: 026336
Schedule:
Testing Time:
Testing Lab: Labcorp
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 2.0 mL
Temperature: Refrigerate/If not tested within 48 hrs then Freeze
Tube Type: Serum
Collection Info:
Minimum Volume: 1.5 mL (Note: This volume does not allow for repeat testing.)
Container: Red-top tube or gel-barrier tube
Collection: To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions: Refrigerate up to 48 hours. Freeze (-20°C) up to two weeks.
Temperature: Refrigerate/If not tested within 48 hrs then Freeze
Tube Type: Serum
Collection Info:
Minimum Volume: 1.5 mL (Note: This volume does not allow for repeat testing.)
Container: Red-top tube or gel-barrier tube
Collection: To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions: Refrigerate up to 48 hours. Freeze (-20°C) up to two weeks.
Specimen Acceptability
Cause for Rejection:
Moderate or excessive hemolysis
Moderate or excessive hemolysis
Methods
Total: kinetic; isoenzymes: agarose gel electrophoresis with densitometry
Clinical Utilities
Diagnose myocardial infarction (MI). Three fractions normally may be found, each an isoenzyme:
• MM is found in normal serum.
• MB is the myocardial fraction associated with MI and occurs in certain other states. MB can be used in estimation of infarct size.
MB increases have been reported with entities that cause damage to the myocardium, such as myocarditis, some instances of cardiomyopathy, and with extensive rhabdomyolysis, Duchenne muscular dystrophy, malignant hyperthermia, polymyositis, dermatomyositis, mixed connective tissue disease, myoglobinemia, Rocky Mountain spotted fever, Reye syndrome, and rarely in rheumatoid arthritis with high titer RF.2 CK-MB does not generally abruptly rise and fall in such nonacute MI settings, as it does in acute myocardial infarct (AMI).
BB is rarely present. BB has been described as a marker for adenocarcinoma of the prostate, breast, ovary, colon, adenocarcinomas of gastrointestinal tract, and for small cell anaplastic carcinoma of lung. BB has been reported with severe shock and/or hypothermia, infarction of bowel,3 brain injury, stroke, as a genetic marker in some families with malignant pyrexia, and with MB in alcoholic myopathy.
• MM is found in normal serum.
• MB is the myocardial fraction associated with MI and occurs in certain other states. MB can be used in estimation of infarct size.
MB increases have been reported with entities that cause damage to the myocardium, such as myocarditis, some instances of cardiomyopathy, and with extensive rhabdomyolysis, Duchenne muscular dystrophy, malignant hyperthermia, polymyositis, dermatomyositis, mixed connective tissue disease, myoglobinemia, Rocky Mountain spotted fever, Reye syndrome, and rarely in rheumatoid arthritis with high titer RF.2 CK-MB does not generally abruptly rise and fall in such nonacute MI settings, as it does in acute myocardial infarct (AMI).
BB is rarely present. BB has been described as a marker for adenocarcinoma of the prostate, breast, ovary, colon, adenocarcinomas of gastrointestinal tract, and for small cell anaplastic carcinoma of lung. BB has been reported with severe shock and/or hypothermia, infarction of bowel,3 brain injury, stroke, as a genetic marker in some families with malignant pyrexia, and with MB in alcoholic myopathy.
CPT Codes
82550 (total); 82552 (isoenzymes)
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
